Check for PSTs
I've had similar issues with certain users. Check with the user to see if they are moving all (or some) of their mail to personal folders. One user in particular that was moving all of his mail to PSTs ended up crashing our system every few hours. RIM said the reason for this was the considerably high error count. If the BES does not find an original message, it will generate an error. If it tries to synch with a message and the message does not exist on the mail server, you will get errors.
It's a case by case basis, but most often, I ask users to move files to their PSTs after a week or two instead of either right away or daily.
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