I had the same problem - it took some detective work, but I finally realized that I had two BES servers (and old one were going to migrate from, and a new one we had just built) that seemed to be "fighting" for a connection to Blackberry. Although I have not had a chance to go deep, my guess is that each BB server needs to have it's own unique public IP address and not share a NAT or PAT address. Once I killed off the old server and migrated the users to the new one, the SRP messages stopped, and the users were no longer getting the red X marks - before it would take three to four attempts to send a message successfully.
Hope that is helpful.
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