I'd have to say that they have a good method of doing QA regression testing for numbers - otherwise, they wouldn't be here today. They have likely put more than 2,000 users into a stable environment, so I'd say that the number they give is more of a low-ball approach (although high enough to be marketable, as well).
I think a major issue you will see with the increasing number of users (even I notice this with simply 80 users on a BES) is the time it takes to load all of the users after a reboot or something similar. With 10 or so users, rebooting the server during the middle of the day will go unnoticeable; however, with a few hundred users, I would imagine that there's a few minutes worth of a delay on message delivery during that time.
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